Friday, December 28, 2007
Improving EvoDevo blog
I just added a sitemeter to my blog today. It created very powerful motivation for me to improve my blog.
If there are any comments which you would like to add, do feel free to let me know. I welcome all feedback.
Another decision I made is to post regularly on every monday so it is easier to know when to expect new posts.
Third, I hope to improve the quality of my writing-its contents and style, and the graphic presentation of my post-more pictures, color, etcetera etcetera.
That's all for now,
Regards,
The Nutty Professor
Saturday, December 22, 2007
Regulatory networks and Evolution of animal body plans
(A note: Davidson and Erwin provided an excellent review discussing how changes gene regulatory networks and evolution of body plans could be linked. Refer to the journal article "Gene regulatory networks and evolution of animal body plans" published in Science in 2006 for a more indepth discussion.)
3. Body plans bear striking similarity with modern phyla
Thursday, December 20, 2007
What I like about Science
Tuesday, December 18, 2007
Researchers find a gene for fear
A key ingredient to a good scientific work is knowing what to look for and using the right method to search for it. With the aim of understanding the neural circuitry controling fear, the place Shumyatsky and group targeted is the amygdala, a region deep in the brain known to contribute to fear and other emotions. In fact the specific site they targeted is the lateral nucleus, the portion of the amygdala that receives stimuli about fear. Thus, the lateral nucleus played a role in processing the fearful stimuli. After dissecting the individual pyramidal cells (principle cell type) in the lateral nucleus, they found two genes, known as gastrin-releasing peptide (GRP) and stathmin.
The experiments which followed are aimed at understanding the genes. Stathmin is characterized by understanding its expression in the brain and its role in controlling fear. A powerful technology used to understand and reveal the role of the gene in controlling fear is the generation of knockout mouse.
Stathmin knockout mouse have memory deficits in conditioned fear and do not have innate fear. Evidence of deficits in conditioned fear come from observation that knockout mice showed a decreased level of freezing immediately after electric shock compared to normal mice. Evidence of lack of innate fear comes from the behavior of mice in a novel environment. Normal mice when placed in a novel open field naturally avoid the open space in the center of the arena while stathmin mutant mice runs in the aversive center of the field. The behavior of mice is quantified by measuring variables such as percentage time spent freezing and time spent in the open space. Other characterization related to the mode of function of stathmin were made. Refer to the paper in Cell, Vol 123, 697.
Tuesday, October 30, 2007
Hopeful monsters
Note how "clean" the transformation from antenna to leg is.
The transformation of one structure of the body did not affect the adjacent structures.
So what does this suggest?
That one structure develops independently of the other neighbouring structures.
Uh huh...but how did mutation cause the leg to end up on the head?
Have you heard of Hox genes? These are really cool genes that determine where limbs and other body segments will grow in a developing embryo.
So in the drosophila embryo, each region is specified by a cluster of Hox genes (below). So does it make sense that one part of the fly develops independently of the other parts?
Here's another blog that explains Hox genes in greater depths.
Sunday, October 28, 2007
Monsters in Science
Here it is.
Left is a normal fly head with antennae. Right is a mutant fly in which the antennae are transformed into legs. (Photos courtesy of Dr Rudy Turner, Indiana University)
Isn't it strange to smile at photographs of flyheads?
Was I amused or was I fascinated? Or have I gone... ...mad?
Mad I wasn't but I sure am fascinated. How on earth did the leg get there? How could changing just one gene change a body so dramatically?
Stay tuned to evodevos.blogspot for the next blogpost.